{"id":347,"date":"2025-04-24T00:27:12","date_gmt":"2025-04-24T00:27:12","guid":{"rendered":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/?page_id=347"},"modified":"2025-04-24T00:48:17","modified_gmt":"2025-04-24T00:48:17","slug":"neuromorphic-bioelectronics","status":"publish","type":"page","link":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/research\/neuromorphic-bioelectronics\/","title":{"rendered":"Neuromorphic bioelectronics"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"646\" height=\"430\" src=\"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-content\/uploads\/sites\/41\/2025\/04\/Bioel-1.webp\" alt=\"\" class=\"wp-image-361\" srcset=\"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-content\/uploads\/sites\/41\/2025\/04\/Bioel-1.webp 646w, https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-content\/uploads\/sites\/41\/2025\/04\/Bioel-1-300x200.webp 300w\" sizes=\"auto, (max-width: 646px) 100vw, 646px\" \/><\/figure>\n<\/div>\n\n\n<p>In this research direction, The integrity of cell barriers is investigated by organic electrochemical transistors (OECTs). Ion transport through cellular barriers via the paracellular pathway is modulated via the tight junctions between adjacent cells. The integrity of bio-membranes\u00a0is monitored by administrating various agents (e.g., neuromodulators, toxins) that induce reversible and irreverible changes of the barrier.\u00a0The proposed platoform represents a versitile tool\u00a0to assess dynamic and critical changes in tight junctions, relevant for clinical applications as drug targeting and screening. Moreover, soft matter-based electronics are used for in-vivo neuromorphic bio-interfaces and for augmenting the sensorimotor processes of living organisms.\u00a0<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\" \/>\n\n\n\n<p><strong>References<\/strong><\/p>\n\n\n\n<p>Pietro Belleri, Judith Pons i Tarr\u00e9s, Iain McCulloch, Paul WM Blom, Zsolt M Kov\u00e1cs-Vajna, Paschalis Gkoupidenis, Fabrizio Torricelli, <em>Unravelling the operation of organic artificial neurons for neuromorphic bioelectronics<\/em>, Nat. Commun. 15, 5350\u00a0(2024).<\/p>\n\n\n\n<p>S. Zhu, Y. Li, H. Yelemulati, X. Deng, Y. Li, J. Wang, X. Li, G. Li, P. Gkoupidenis, Y. Tai,&nbsp;<em>An artificial remote tactile device with 3D depth-of-field sensation<\/em>, Sci. Adv. 8, 43 (2022).<\/p>\n\n\n\n<p>T. Sarkar, K. Lieberth, A. Pavlou, T. Frank, V. Mailaender, I. McCulloch, P. W. M. Blom, F. Torricelli, P. Gkoupidenis,&nbsp;<em>An organic artificial spiking neuron&nbsp;for in situ neuromorphic sensing and biointerfacing<\/em>, Nat. Electron.&nbsp;5 (11), 774-783 (2022).<\/p>\n\n\n\n<p>R. Nawrocki, M. Parker, P. Gkoupidenis,&nbsp;<em>Artificial neurons emulate biological counterparts to enable synergetic operation,&nbsp;<\/em>Nat. Electr. 5 (11), 721-722 (2022).<\/p>\n\n\n\n<p>K. Lieberth, M. Br\u00fcckner, F. Torricelli, V. Mail\u00e4nder, P. Gkoupidenis, P. W. M. Blom,&nbsp;<em>Monitoring reversible tight junction modulation with a current\u2010driven organic electrochemical transistor<\/em>, Adv. Mater. Technol. 2000940 (2021).<\/p>\n\n\n\n<p>K. Lieberth, P. Romele, F. Torricelli, D. A. Koutsouras, M. Br\u00fcckner, V. Mail\u00e4nder, P. Gkoupidenis, P. W. M. Blom,&nbsp;<em>Current-driven organic electrochemical transistors for monitoring cell layer integrity with enhanced sensitivity<\/em>, Adv. Healthc. Mater. 2100845 (2021).<\/p>\n\n\n\n<p>L. V. Lingstedt, M. Ghittorelli, M. Br\u00fcckner, J. Reinholz, I. Cr\u0103ciun, F. Torricelli, V. Mail\u00e4nder, P. Gkoupidenis, P. W. M. Blom,&nbsp;<em>Monitoring of cell layer integrity with a current\u2010driven organic electrochemical transistor<\/em>, Adv. Healthc. Mater. 8, 16, 1900128 (2019).<\/p>\n\n\n\n<p>D. Koutsouras, L. V. Lingstedt, K. Lieberth, J. Reinholz, V. Mail\u00e4nder, P. W. M. Blom, P. Gkoupidenis,&nbsp;<em>Probing the impedance of a biological tissue with PEDOT:PSS\u2010coated metal electrodes: Effect of electrode size on sensing efficiency<\/em>, Adv. Healthc. Mater. 8, 23, 1901215 (2019).<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this research direction, The integrity of cell barriers is investigated by organic electrochemical transistors (OECTs). Ion transport through cellular barriers via the paracellular pathway&#8230;<\/p>\n","protected":false},"author":150,"featured_media":0,"parent":17,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-347","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/pages\/347","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/users\/150"}],"replies":[{"embeddable":true,"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/comments?post=347"}],"version-history":[{"count":4,"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/pages\/347\/revisions"}],"predecessor-version":[{"id":364,"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/pages\/347\/revisions\/364"}],"up":[{"embeddable":true,"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/pages\/17"}],"wp:attachment":[{"href":"https:\/\/research.ece.ncsu.edu\/gkoupidenis\/wp-json\/wp\/v2\/media?parent=347"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}