Imaging of in vitro
parenteral drug
precipitation

Solid particulate matter introduced into the bloodstream as a result of parenteral drug administration can produce serious pathological conditions. Particulate matter that cannot be eliminated by pre-infusion
filtration is often the result of drug precipitation that occurs when certain parenteral formulations are mixed with blood. A new device is designed to model the mixing of drug formulations with flowing blood utilizing a uniquely designed flow cell and a CCD camera to view the formulation as it is mixed with a blood surrogate in real time. The performance of the proposed device is measured using 3 commercially available parenteral formulations previously tested using a validated in vitro model.

D. C. Evans, M. W. Kudenov, K. C. Sassenrath, E. L. Dereniak, and S. H. Yalkowsky, “Imaging of in vitro parenteral drug precipitation,” International Journal of Pharmaceutics 512, 219–223 (2016).