{"id":469,"date":"2017-03-31T21:17:49","date_gmt":"2017-03-31T21:17:49","guid":{"rendered":"https:\/\/beta.research.ece.ncsu.edu\/osl\/?p=469"},"modified":"2017-03-31T21:17:49","modified_gmt":"2017-03-31T21:17:49","slug":"imaging-of-in-vitro-parenteral-drug-precipitation","status":"publish","type":"post","link":"https:\/\/research.ece.ncsu.edu\/osl\/2017\/03\/31\/imaging-of-in-vitro-parenteral-drug-precipitation\/","title":{"rendered":"Imaging of in vitro   parenteral drug   precipitation"},"content":{"rendered":"<p><span class=\"fontstyle0\">Solid particulate matter introduced into the bloodstream as a result of parenteral drug administration can produce serious pathological conditions. Particulate matter that cannot be eliminated by pre-infusion<br \/>\n<\/span><span class=\"fontstyle2\">fi<\/span><span class=\"fontstyle0\">ltration is often the result of drug precipitation that occurs when certain parenteral formulations are mixed with blood. A new device is designed to model the mixing of drug formulations with <\/span><span class=\"fontstyle2\">fl<\/span><span class=\"fontstyle0\">owing blood utilizing a uniquely designed <\/span><span class=\"fontstyle2\">fl<\/span><span class=\"fontstyle0\">ow cell and a CCD camera to view the formulation as it is mixed with a blood surrogate in real time. The performance of the proposed device is measured using 3 commercially available parenteral formulations previously tested using a validated in vitro model.<\/span><\/p>\n<div class=\"csl-bib-body\">\n<div class=\"csl-entry\">\n<div class=\"csl-left-margin\">D. C. Evans, M. W. Kudenov, K. C. Sassenrath, E. L. Dereniak, and S. H. Yalkowsky, &#8220;Imaging of in vitro parenteral drug precipitation,&#8221; International Journal of Pharmaceutics <b>512<\/b>, 219\u2013223 (2016).<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Solid particulate matter introduced into the bloodstream as a result of parenteral drug administration can produce serious pathological conditions. Particulate matter that cannot be eliminated&#8230;<\/p>\n","protected":false},"author":103,"featured_media":470,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[6],"tags":[],"class_list":["post-469","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research-papers"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/posts\/469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/users\/103"}],"replies":[{"embeddable":true,"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/comments?post=469"}],"version-history":[{"count":1,"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/posts\/469\/revisions"}],"predecessor-version":[{"id":471,"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/posts\/469\/revisions\/471"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/media\/470"}],"wp:attachment":[{"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/media?parent=469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/categories?post=469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/research.ece.ncsu.edu\/osl\/wp-json\/wp\/v2\/tags?post=469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}